@article {133,
	title = {DNA REPAIR. Mus81 and converging forks limit the mutagenicity of replication fork breakage.},
	journal = {Science},
	volume = {349},
	year = {2015},
	month = {2015 Aug 14},
	pages = {742-7},
	abstract = {<p>Most spontaneous DNA double-strand breaks (DSBs) result from replication-fork breakage. Break-induced replication (BIR), a genome rearrangement-prone repair mechanism that requires the Pol32/POLD3 subunit of eukaryotic DNA Polδ, was proposed to repair broken forks, but how genome destabilization is avoided was unknown. We show that broken fork repair initially uses error-prone Pol32-dependent synthesis, but that mutagenic synthesis is limited to within a few kilobases from the break by Mus81 endonuclease and a converging fork. Mus81 suppresses template switches between both homologous sequences and diverged human Alu repetitive elements, highlighting its importance for stability of highly repetitive genomes. We propose that lack of a timely converging fork or Mus81 may propel genome instability observed in cancer. </p>},
	keywords = {Alu Elements, Base Sequence, DNA Breaks, Double-Stranded, DNA Repair, DNA Replication, DNA-Binding Proteins, DNA-Directed DNA Polymerase, Endonucleases, Genomic Instability, Humans, Molecular Sequence Data, Neoplasms, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins},
	issn = {1095-9203},
	doi = {10.1126/science.aaa8391},
	author = {Mayle, Ryan and Campbell, Ian M and Beck, Christine R and Yu, Yang and Wilson, Marenda and Shaw, Chad A and Bjergbaek, Lotte and Lupski, James R and Ira, Grzegorz}
}
