@article {1020,
	title = {Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19.},
	journal = {bioRxiv},
	year = {2021},
	month = {2021 Mar 10},
	abstract = {<p>Type I interferon (IFN-I) neutralizing autoantibodies have been found in some critical COVID-19 patients; however, their prevalence and longitudinal dynamics across the disease severity scale, and functional effects on circulating leukocytes remain unknown. Here, in 284 COVID-19 patients, we found IFN-I autoantibodies in 19\% of critical, 6\% of severe and none of the moderate cases. Longitudinal profiling of over 600,000 peripheral blood mononuclear cells using multiplexed single-cell epitope and transcriptome sequencing from 54 COVID-19 patients, 15 non-COVID-19 patients and 11 non-hospitalized healthy controls, revealed a lack of IFN-I stimulated gene (ISG-I) response in myeloid cells from critical cases, including those producing anti-IFN-I autoantibodies. Moreover, surface protein analysis showed an inverse correlation of the inhibitory receptor LAIR-1 with ISG-I expression response early in the disease course. This aberrant ISG-I response in critical patients with and without IFN-I autoantibodies, supports a unifying model for disease pathogenesis involving ISG-I suppression via convergent mechanisms.</p>},
	doi = {10.1101/2021.03.09.434529},
	author = {van der Wijst, Monique G P and Vazquez, Sara E and Hartoularos, George C and Bastard, Paul and Grant, Tianna and Bueno, Raymund and Lee, David S and Greenland, John R and Sun, Yang and Perez, Richard and Ogorodnikov, Anton and Ward, Alyssa and Mann, Sabrina A and Lynch, Kara L and Yun, Cassandra and Havlir, Diane V and Chamie, Gabriel and Marquez, Carina and Greenhouse, Bryan and Lionakis, Michail S and Norris, Philip J and Dumont, Larry J and Kelly, Kathleen and Zhang, Peng and Zhang, Qian and Gervais, Adrian and Voyer, Tom Le and Whatley, Alexander and Si, Yichen and Byrne, Ashley and Combes, Alexis J and Rao, Arjun Arkal and Song, Yun S and Fragiadakis, Gabriela K and Kangelaris, Kirsten and Calfee, Carolyn S and Erle, David J and Hendrickson, Carolyn and Krummel, Matthew F and Woodruff, Prescott G and Langelier, Charles R and Casanova, Jean-Laurent and Derisi, Joseph L and Anderson, Mark S and Ye, Chun Jimmie}
}
@article {1025,
	title = {Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma.},
	journal = {J Clin Immunol},
	year = {2021},
	month = {2021 May 19},
	issn = {1573-2592},
	doi = {10.1007/s10875-021-01060-0},
	author = {Vazquez, Sara E and Bastard, Paul and Kelly, Kathleen and Gervais, Adrian and Norris, Philip J and Dumont, Larry J and Casanova, Jean-Laurent and Anderson, Mark S and Derisi, Joseph L}
}
